Pathological impact of hepatitis B virus surface proteins on the liver is associated with the host genetic background.

ABSTRACT:

Background

While the immune pathogenesis caused by hepatitis B virus (HBV) infection has been studied extensively, little is known about direct pathogenic effects of HBV surface proteins. Here, we have investigated pathological cellular effects of HBV surface protein expression in the liver of transgenic mice with different genetic background.

Methods

The impact of HBV surface protein expression on the liver was studied in two mouse strains, BALB/c and C57BL/6. Histology and hydroxyproline assays were performed to investigate liver morphology and fibrosis. Gene expression and signaling were analyzed by microarray, qPCR and Western blotting.

Results

Expression of HBV surface proteins in the liver of transgenic mice induced activation of protein kinase-like endoplasmic

SUBMITTER: Churin Y 

PROVIDER: S-EPMC3942466 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature