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Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.

ABSTRACT: Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The crucial role of RNR in DNA synthesis has made it an important target for the development of antiviral and anticancer drugs. Taking account of the recent developments in this field of research, this review focuses on the role of thioredoxin and glutaredoxin systems in the redox reactions of the RNR catalysis.

SUBMITTER: Sengupta R 

PROVIDER: S-EPMC3942543 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.

Sengupta Rajib R   Holmgren Arne A  

World journal of biological chemistry 20140201 1

Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The crucial role of RNR in DNA synthesis has made it an important target for the development of antiviral and anticancer drugs. Taking account of the recent developments in this field of research, this review focuses on the role of thioredoxin and glutaredoxin systems in the redox reactions of the RNR catalysis. ...[more]

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