RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population.

ABSTRACT:

Aim

To investigate the association of three polymorphisms in the receptor for advanced glycation end product (RAGE) gene with Crohn's disease (CD) risk in a Chinese population.

Methods

A hospital-based case-control association study involving 312 CD patients and 479 healthy controls was conducted. Peripheral blood samples were collected from 791 study subjects, and genomic DNA was extracted. Genotyping was performed using polymerase chain reaction-ligase detection reaction method. The association between polymorphic genotype and CD predisposition was determined using odds ratio and 95% confidence interval (CI). Data were analyzed using Haplo.stats program.

Results

Significant differences were observed between patients and controls in allele/genotype distributions of r

SUBMITTER: Wang ZT 

PROVIDER: S-EPMC3942844 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature