Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase.

ABSTRACT: High counts of circulating microparticles, originated from the membrane of abnormal erythrocytes, have been associated with increased thrombotic risk in hemolytic disorders. Our studies indicate that in thalassemia intermedia patients the number of circulating microparticles correlates with the capability of the thalassemic erythrocytes to release microparticles. The microparticles are characteristically loaded with hemichromes formed by denatured α-chains. This finding was substantiated by the positive correlation observed in thalassemia intermedia patients between the amount of hemichromes measured in erythrocytes, their capability to release microparticles and the levels of plasma hemichromes. We observed that hemichromes, following their binding to the cytoplasmic domain of band 3, ind

SUBMITTER: Ferru E 

PROVIDER: S-EPMC3943323 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature