Intramolecular hydroamination of dithioketene acetals: an easy route to cyclic amino acid derivatives.

ABSTRACT: Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.

SUBMITTER: Xu HC 

PROVIDER: S-EPMC3943425 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature