Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids.

ABSTRACT:

Scope

In contrast to well-characterized PUFA levels in serum, little is known regarding their downstream metabolic products. However, many of these compounds are lipid mediators with prominent roles during pro- and antiinflammatory processes.

Methods and results

In this double blind crossover study on asthmatics, shifts in serum levels of ω-3 and ω-6 PUFA-derived oxidized fatty acids (e.g. eicosanoids, oxylipins) were quantified following dietary fish oil supplementation. Serum was obtained from subjects following fasting at three occasions; (i) prior to supplementation, (ii) following a 3-week supplement intake of either placebo or fish oil, and (iii) following a 3-week washout period with a subsequent 3-week period of either fish oil or placebo supplement. A total of 87 ox

SUBMITTER: Lundstrom SL 

PROVIDER: S-EPMC3943463 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature