DSM-5 cannabis use disorder: a phenotypic and genomic perspective.

ABSTRACT:

Background

We explore the factor structure of DSM-5 cannabis use disorders, examine its prevalence across European- and African-American respondents as well as its genetic underpinnings, utilizing data from a genome-wide study of single nucleotide polymorphisms (SNPs). We also estimate the heritability of DSM-5 cannabis use disorders explained by these common SNPs.

Methods

Data on 3053 subjects reporting a lifetime history of cannabis use were utilized. Exploratory and confirmatory factor analyses were conducted to create a factor score, which was used in a genome-wide association analysis. p-values from the single SNP analysis were examined for evidence of gene-based association. The aggregate effect of all SNPs was also estimated using Genome-Wide Complex Traits Analysis.<

SUBMITTER: Agrawal A 

PROVIDER: S-EPMC3943464 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature