A voxel-based morphometry study of young occasional users of amphetamine-type stimulants and cocaine.

ABSTRACT:

Background

Although the interaction of brain volume with amphetamine-type stimulants (ATS) and cocaine has been investigated in chronically dependent individuals, little is known about structural differences that might exist in individuals who consume ATS and cocaine occasionally but are not dependent on these drugs.

Methods

Regional brain volumes in 165 college aged occasional users of ATS (namely: amphetamine, methamphetamine, methylphenidate, and 3,4-methylenedioxymethamphetamine; MDMA) and cocaine were compared by voxel-based morphometry with 48 ATS/cocaine-naive controls.

Results

Grey matter volume was significantly higher in the left ventral anterior putamen of occasional users, and lower in the right dorsolateral cerebellum and right inferior parietal cortex. A

SUBMITTER: Mackey S 

PROVIDER: S-EPMC3943469 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature