No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.

ABSTRACT: Genome-wide association studies have been successful in identifying common variants that influence the susceptibility to complex diseases. From these studies, it has emerged that there is substantial overlap in susceptibility loci between diseases. In line with those findings, we hypothesized that shared genetic pathways may exist between multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). While both diseases may have inflammatory and neurodegenerative features, epidemiological studies have indicated an increased co-occurrence within individuals and families. To this purpose, we combined genome-wide data from 4088 MS patients, 3762 ALS patients and 12 030 healthy control individuals in whom 5 440 446 single-nucleotide polymorphisms (SNPs) were successfully genotyped or imputed

SUBMITTER: Goris A 

PROVIDER: S-EPMC3943520 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature