Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common skin disease characterized by recurrent episodes of itching. Genetic variation associated with the persistence of AD has not been described for African American subjects.

Objective

We sought to evaluate genetic variation of filaggrin-2 (FLG2) in African American subjects with AD.

Methods

We evaluated a multiyear prospective cohort study of African American children with AD with respect to FLG2 variation based on whole-exome sequencing, followed by a targeted analysis. We ultimately evaluated the association of rs12568784 and rs16833974 with respect to the persistence of AD symptoms over time.

Results

Whole-exome analysis was conducted on 60 subjects, revealing a premature stop codon in exon 3 at S2377X (rs12568784)

SUBMITTER: Margolis DJ 

PROVIDER: S-EPMC3943564 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature