Dataset Information

Development of cockroach immunotherapy by the Inner-City Asthma Consortium.

ABSTRACT:

Background

Cockroach allergy is a key contributor to asthma morbidity in children living in urban environments.

Objective

We sought to document immune responses to cockroach allergen and provide direction for the development of immunotherapy for cockroach allergy.

Methods

Four pilot studies were conducted: (1) an open-label study to assess the safety of cockroach sublingual immunotherapy (SLIT) in adults and children; (2) a randomized, double-blind biomarker study of cockroach SLIT versus placebo in adults; (3) a randomized, double-blind biomarker study of 2 doses of cockroach SLIT versus placebo in children; and (4) an open-label safety and biomarker study of cockroach subcutaneous immunotherapy (SCIT) in adults.