Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.

ABSTRACT: A significant number of children undergo maternal exposure to antidepressants and they often present low birth weight. Therefore, it is important to understand how selective serotonin reuptake inhibitors (SSRIs) affect the development of the hypothalamus, the key center for metabolism regulation. In this study we investigated the proliferative actions of fluoxetine in fetal hypothalamic neuroprogenitor cells and demonstrate that fluoxetine induces the proliferation of these cells, as shown by increased neurospheres size and number of proliferative cells (Ki-67+ cells). Moreover, fluoxetine inhibits the differentiation of hypothalamic neuroprogenitor cells, as demonstrated by decreased number of mature neurons (Neu-N+ cells) and increased number of undifferentiated cells (SOX-2+ cells). Add

SUBMITTER: Sousa-Ferreira L 

PROVIDER: S-EPMC3943792 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature