Gene expression profiling of CD4⁺ T cells in treatment-naive HIV, HCV mono- or co-infected Chinese.

ABSTRACT:

Background

Because of the shared transmission routes, co-infection with human immunodeficiency virus (HIV) and hepatitis C virus (HIV) is very common. Accumulated clinical evidence showed that one could alter the infectious course of the other virus in HIV and HCV co-infected individuals. However, little is known on the molecular basis of HIV/HCV interactions and their modulations on hosts.

Methods

In this study, treatment-naive HIV, HCV mono-/co-infected individuals with CD4⁺ T cell counts >300/μl were recruited and their gene expression profiles were investigated by microarray assays. The differentially expressed genes were identified and validated by quantitative real-time PCR (qRT-PCR). To further understand the biological meanings of the gene expression profiles in thes

SUBMITTER: Yi L 

PROVIDER: S-EPMC3943807 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature