Interactive effects of in utero nutrition and genetic inheritance on cognition: new evidence using sibling comparisons.

ABSTRACT: A large literature links early environments and later outcomes, such as cognition; however, little is known about the mechanisms. One potential mechanism is sensitivity to early environments that is moderated or amplified by the genotype. With this mechanism in mind, a complementary literature outside economics examines the interaction between genes and environments, but often problems of endogeneity and bias in estimation are uncorrected. A key issue in the literature is exploring environmental variation that is not exogenous, which is potentially problematic if there are gene-environment correlation or gene-gene interactions. Using sibling pairs with genetic data in the Wisconsin Longitudinal Study we extend a previous, and widely cited, gene-environment study that explores an interactio

SUBMITTER: Cook CJ 

PROVIDER: S-EPMC3943815 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature