Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium.

ABSTRACT:

Background

Risk of non-Hodgkin lymphoma (NHL) is higher among individuals with a family history or a prior diagnosis of other cancers. Genome-wide association studies (GWAS) have suggested that some genetic susceptibility variants are associated with multiple complex traits (pleiotropy).

Objective

We investigated whether common risk variants identified in cancer GWAS may also increase the risk of developing NHL as the first primary cancer.

Methods

As part of the Population Architecture using Genomics and Epidemiology (PAGE) consortium, 113 cancer risk variants were analyzed in 1,441 NHL cases and 24,183 controls from three studies (BioVU, Multiethnic Cohort Study, Women's Health Initiative) for their association with the risk of overall NHL and common subtypes [diffus

SUBMITTER: Lim U 

PROVIDER: S-EPMC3943855 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature