Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.

ABSTRACT:

Background & aims

Postprandial glycemia excursions increase after gastric bypass surgery; this effect is even greater among patients with recurrent hypoglycemia. These patients also have increased postprandial levels of insulin and glucagon-like peptide 1 (GLP-1). We performed a clinical trial to determine the role of GLP-1 in postprandial glycemia in patients with hyperinsulinemic hypoglycemia syndrome after gastric bypass.

Methods

Nine patients with recurrent hypoglycemia after gastric bypass (H-GB), 7 patients who were asymptomatic after gastric bypass (A-GB), and 8 healthy control subjects underwent a mixed-meal tolerance test (350 kcal) using a dual glucose tracer method on 2 separate days. On 1 day they received continuous infusion of the GLP-1 receptor antagonist exen

SUBMITTER: Salehi M 

PROVIDER: S-EPMC3943944 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature