Distinct cellular origins for serotonin-expressing and enterochromaffin-like cells in the gastric corpus.

ABSTRACT:

Background & aims

The alimentary tract contains a diffuse endocrine system comprising enteroendocrine cells that secrete peptides or biogenic amines to regulate digestion, insulin secretion, food intake, and energy homeostasis. Lineage analysis in the stomach revealed that a significant fraction of endocrine cells in the gastric corpus did not arise from Neurogenin3 (Neurog3)-expressing cells, unlike enteroendocrine cells elsewhere in the digestive tract. We aimed to isolate enriched serotonin-secreting and enterochromaffin-like (ECL) cells from the stomach and to clarify their cellular origin.

Methods

We used Neurogenic differentiation 1 (NeuroD1) and Neurog3 lineage analysis and examined the differentiation of serotonin-producing and ECL cells in stomach tissues of NeuroD1

SUBMITTER: Li HJ 

PROVIDER: S-EPMC3943955 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature