Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.

ABSTRACT:

Background

Effects of beta-blockers on the prognosis of the heart failure patients with preserved ejection fraction (HFpEF) remain controversial. The aim of this meta-analysis was to determine the impact of beta-blockers on mortality and hospitalization in the patients with HFpEF.

Methods

A search of MEDLINE, EMBASE, and the Cochrane Library databases from 2005 to June 2013 was conducted. Clinical studies reporting outcomes of mortality and/or hospitalization for patients with HFpEF (EF ≥ 40%), being assigned to beta-blockers treatment and non-beta-blockers control group were included.

Results

A total of 12 clinical studies (2 randomized controlled trials and 10 observational studies) involving 21,206 HFpEF patients were included for this meta-analysis. The pooled ana

SUBMITTER: Liu F 

PROVIDER: S-EPMC3944014 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature