Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.

ABSTRACT: Developmental defects and disruption of molecular pathways of the cardiac conduction system (CCS) can cause life-threatening cardiac arrhythmias. Despite decades of effort, knowledge about the development and molecular control of the CCS remains primitive. Mouse genetics, complementary to other approaches such as human genetics, has become a key tool for exploring the developmental processes of various organs and associated diseases. Genetic analysis using mouse models will likely provide great insights about the development of the CCS, which can facilitate the development of novel therapeutic strategies to treat arrhythmias. To enable genetic studies of the CCS, CCS-associated Cre mouse models are essential. However, existing mouse models with Cre activity reported in the CCS have various

SUBMITTER: Wu M 

PROVIDER: S-EPMC3944086 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature