Angiotensin-converting enzyme inhibitor, angiotensin receptor blocker use, and mortality in patients with chronic kidney disease.

ABSTRACT:

Objectives

The study objective was to assess the association between angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) use and mortality in patients with chronic kidney disease (CKD).

Background

There is insufficient evidence about the association of ACEI or ARBs with mortality in patients with CKD.

Methods

A logistic regression analysis was used to calculate the propensity of ACEI/ARB initiation in 141,413 U.S. veterans with nondialysis CKD who were previously unexposed to ACEI/ARB treatment. We examined the association of ACEI/ARB administration with all-cause mortality in patients matched by propensity scores using the Kaplan-Meier method and Cox models in "intention-to-treat" analyses and in generalized linear models with binary out

SUBMITTER: Molnar MZ 

PROVIDER: S-EPMC3944089 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature