Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome.

ABSTRACT:

Background

The congenital long-QT syndrome (LQTS) is an important cause of sudden cardiac death in children without structural heart disease. However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified.

Methods and results

Cox proportional-hazards regression modeling was used to identify risk factors for aborted cardiac arrest or sudden cardiac death in 3015 LQTS children from the International LQTS Registry who were followed up from 1 through 12 years of age. The cumulative probability of the combined end point was significantly higher in boys (5%) than in girls (1%; P<0.001). Risk factors for cardiac arrest or sudden cardiac death during childhood included corrected QT interval [QTc] duration > 500 ms (

SUBMITTER: Goldenberg I 

PROVIDER: S-EPMC3944375 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature