Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit.

ABSTRACT: Androgen receptor signaling is critical in the development and progression of prostate cancer, leading to intensive efforts to elucidate all potential points of inflection for therapeutic intervention. These efforts have revealed new mechanisms of resistance and raise the possibility that known mechanisms may become even more relevant in the context of effective androgen receptor suppression. These mechanisms include tumoral appropriation of alternative androgen sources, alterations in androgen receptor expression, androgen receptor mutations, truncated androgen receptor variants, alterations and cross-talk in recruitment of cofactors to androgen receptor binding sites in the genome, and androgen receptor-driven oncogenic gene fusions. New agents such as enzalutamide, EPI-001, androgen rec

SUBMITTER: Mostaghel EA 

PROVIDER: S-EPMC3944407 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature