Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men.

ABSTRACT:

Aim

To determine the association between the number of thymine-adenine (TA)n dinucleotide repeats in the promoter region of the gene coding for the estrogen receptor alpha (ESR1) and the prevalence of lone atrial fibrillation (AF) in men.

Methods

We conducted a case-control study involving 89 men with lone AF and 166 healthy male controls. The ESR1 genotype was established by polymerase chain reaction and capillary electrophoresis. To assess the association of ESR1 genotype with AF, logistic regression models were built with AF as outcome.

Results

Men with lone AF had significantly greater number of (TA)n repeats of single alleles than controls (mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010). After adjustment for other factors, a unit-increase in (TA)n

SUBMITTER: Golubic K 

PROVIDER: S-EPMC3944416 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature