Ontology highlight
ABSTRACT:
SUBMITTER: Siebzehnrubl FA
PROVIDER: S-EPMC3944461 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20130701 8
Glioblastoma remains one of the most lethal types of cancer, and is the most common brain tumour in adults. In particular, tumour recurrence after surgical resection and radiation invariably occurs regardless of aggressive chemotherapy. Here, we provide evidence that the transcription factor ZEB1 (zinc finger E-box binding homeobox 1) exerts simultaneous influence over invasion, chemoresistance and tumourigenesis in glioblastoma. ZEB1 is preferentially expressed in invasive glioblastoma cells, w ...[more]