Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp.

ABSTRACT: Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-¹³C glucose, and analysis of a ¹³C-¹³C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).

SUBMITTER: Ellis GA 

PROVIDER: S-EPMC3944528 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature