Krempfielins N-P, New anti-inflammatory eunicellins from a Taiwanese soft coral Cladiella krempfi.

ABSTRACT: Three new eunicellin-type diterpenoids, krempfielins N-P (1-3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.

SUBMITTER: Lee YN 

PROVIDER: S-EPMC3944535 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature