ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma.

ABSTRACT:

Background

An association between cigarette smoking and increased risk of clear cell renal cell carcinoma (ccRCC) has been established; however, there are limited data regarding the molecular mechanisms that underlie this association. We used a multi-stage design to identify and validate genes that are associated with smoking-related ccRCC.

Methods

We first conducted a microarray study to compare gene expression patterns in patient-matched ccRCC and normal kidney tissues between patients with (n = 23) and without (n = 42) a history of smoking. Analyses were first stratified on obesity status (the other primary risk factor for ccRCC) and then combined and analyzed together. To identify genes where the fold change in smokers relative to non-smokers was different in tumor tissu

SUBMITTER: Eckel-Passow JE 

PROVIDER: S-EPMC3944917 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature