Alterations in lung gene expression in streptozotocin-induced diabetic rats.

ABSTRACT:

Background

Diabetes profoundly affects gene expression in organs such as heart, skeletal muscle, kidney and liver, with areas of perturbation including carbohydrate and lipid metabolism, oxidative stress, and protein ubiquitination. Type 1 diabetes impairs lung function, but whether gene expression alterations in the lung parallel those of other tissue types is largely unexplored.

Methods

Lung from a rat model of diabetes mellitus induced by streptozotocin was subjected to gene expression microarray analysis.

Results

Glucose levels were 67 and 260 mg/dl (p < 0.001) in control and diabetic rats, respectively. There were 46 genes with at least ± 1.5-fold significantly altered expression (19 increases, 27 decreases). Gene ontology groups with significant over-representat

SUBMITTER: van Lunteren E 

PROVIDER: S-EPMC3945062 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature