Lipoprotein(a) for risk assessment in patients with established coronary artery disease.

ABSTRACT:

Objectives

The purpose of this study was to assess the prognostic utility of lipoprotein(a) [Lp(a)] in individuals with coronary artery disease (CAD).

Background

Data regarding an association between Lp(a) and cardiovascular (CV) risk in secondary prevention populations are sparse.

Methods

Plasma Lp(a) was measured in 6,708 subjects with CAD from 3 studies; data were then combined with 8 previously published studies for a total of 18,978 subjects.

Results

Across the 3 studies, increasing levels of Lp(a) were not associated with the risk of CV events when modeled as a continuous variable (odds ratio [OR]: 1.03 per log-transformed SD, 95% confidence interval [CI]: 0.96 to 1.11) or by quintile (Q5:Q1 OR: 1.05, 95% CI: 0.83 to 1.34). When data were combined with pr

SUBMITTER: O'Donoghue ML 

PROVIDER: S-EPMC3945105 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature