Quantitative protein localization signatures reveal an association between spatial and functional divergences of proteins.

ABSTRACT: Protein subcellular localization is a major determinant of protein function. However, this important protein feature is often described in terms of discrete and qualitative categories of subcellular compartments, and therefore it has limited applications in quantitative protein function analyses. Here, we present Protein Localization Analysis and Search Tools (PLAST), an automated analysis framework for constructing and comparing quantitative signatures of protein subcellular localization patterns based on microscopy images. PLAST produces human-interpretable protein localization maps that quantitatively describe the similarities in the localization patterns of proteins and major subcellular compartments, without requiring manual assignment or supervised learning of these compartments. Usi

SUBMITTER: Loo LH 

PROVIDER: S-EPMC3945119 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature