Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.

ABSTRACT: Endometriosis is a gynecological disease defined by the extrauterine growth of endometrial-like cells that cause chronic pain and infertility. The disease is limited to primates that exhibit spontaneous decidualization, and diseased cells are characterized by significant defects in the steroid-dependent genetic pathways that typify this process. Altered DNA methylation may underlie these defects, but few regions with differential methylation have been implicated in the disease. We mapped genome-wide differences in DNA methylation between healthy human endometrial and endometriotic stromal cells and correlated this with gene expression using an interaction analysis strategy. We identified 42,248 differentially methylated CpGs in endometriosis compared to healthy cells. These extensive diffe

SUBMITTER: Dyson MT 

PROVIDER: S-EPMC3945170 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature