PROX1 gene variant is associated with fasting glucose change after antihypertensive treatment.

ABSTRACT:

Study objective

To assess the relationship of the 33 single nucleotide polymorphisms (SNPs) previously associated with fasting glucose in Caucasians in genome-wide association studies (GWAS) with glucose response to antihypertensive drugs shown to increase risk for hyperglycemia and diabetes.

Design

Randomized, multicenter clinical trial.

Patients

A total of 456 Caucasian men and women with uncomplicated hypertension.

Measurements and main results

The Pharmacogenomic Evaluation of Antihypertensives Responses study evaluated blood pressure and glucose response in uncomplicated hypertensive patients randomized to either atenolol or hydrochlorothiazide (HCTZ) monotherapy, followed by combination therapy with both agents. Association of these SNPs with atenolol- or

SUBMITTER: Gong Y 

PROVIDER: S-EPMC3945213 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature