Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

ABSTRACT:

Objectives

To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality.

Design

Cross-sectional study.

Setting

Baltimore Longitudinal Study of Aging.

Participants

Seven hundred eighty-six individuals with a mean age of 66.3 (range 26-96) (N = 786). A sensitivity analysis was conducted in a subset of participants matched according to sex, muscle mass, and body size.

Measurements

Muscle quality was operationalized as the ratio of knee-extension strength (isokinetic dynamometry) to thigh muscle cross-sectional area (computed tomography). Differences in muscle strength, muscle area, and muscle quality rati

SUBMITTER: Moore AZ 

PROVIDER: S-EPMC3945403 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature