Identification of a type IV secretion substrate of Brucella abortus that participates in the early stages of intracellular survival.

ABSTRACT: Brucella abortus, the aetiological agent of bovine brucellosis, is an intracellular pathogen whose virulence is completely dependent on a type IV secretion system. This secretion system translocates effector proteins into the host cell to modulate the intracellular fate of the bacterium in order to establish a secure niche were it actively replicates. Although much has been done in understanding how this secretion system participates in the virulence process, few effector proteins have been identified to date. We describe here the identification of a type IV secretion substrate (SepA) that is only present in Brucella spp. and has no detectable homology to known proteins. This protein is secreted in a virB-dependent manner in a two-step process involving a periplasmic intermediate and secre

SUBMITTER: Dohmer PH 

PROVIDER: S-EPMC3945426 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature