Early pediatric antiepileptic drug nonadherence is related to lower long-term seizure freedom.

ABSTRACT:

Objective

To examine the relationship between previously identified nonadherence trajectories during the first 6 months of antiepileptic drug (AED) therapy and long-term seizure-free rates (defined as ≥1 year of seizure freedom at the 4 years postdiagnosis milestone) in a cohort of children with newly diagnosed epilepsy.

Methods

A prospective longitudinal observational study of AED adherence and seizure freedom in a consecutive cohort of 124 children (ages 2-12 years) with newly diagnosed epilepsy was conducted. The association between previously identified AED adherence trajectories (i.e., near-perfect adherence [e.g., average adherence = 96.8%] vs nonadherent) and seizure freedom for ≥1 year at the 4 years postdiagnosis milestone was determined.

Results

Children who

SUBMITTER: Modi AC 

PROVIDER: S-EPMC3945661 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature