Effect of dengue-2 virus infection on protein expression in the salivary glands of Aedes aegypti mosquitoes.

ABSTRACT: Dengue virus (DENV) is the most important mosquito-transmitted flavivirus that is transmitted throughout the tropical and subtropical regions of the world. The primary mosquito vector of DENV in urban locations is Aedes aegypti. Key to understanding the transmission of DENV is the relationship between pathogen and vector. Accordingly, we report our preliminary characterization of the differentially expressed proteins from Ae. aegypti mosquitoes after DENV infection. We investigated the virus-vector interaction through changes in the proteome of the salivary glands of mosquitoes with disseminated DENV serotype 2 (DENV-2) infections using two-dimensional gel electrophoresis and identification by mass spectrometry. Our findings indicate that DENV-2 infection in the Ae. aegypti salivary gland

SUBMITTER: Chisenhall DM 

PROVIDER: S-EPMC3945687 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature