Discovery of novel disease-specific and membrane-associated candidate markers in a mouse model of multiple sclerosis.

ABSTRACT: Multiple sclerosis is a chronic demyelinating disorder characterized by the infiltration of auto-reactive immune cells from the periphery into the central nervous system resulting in axonal injury and neuronal cell death. Experimental autoimmune encephalomyelitis represents the best characterized animal model as common clinical, histological, and immunological features are recapitulated. A label-free mass spectrometric proteomics approach was used to detect differences in protein abundance within specific fractions of disease-affected tissues including the soluble lysate derived from the spinal cord and membrane protein-enriched peripheral blood mononuclear cells. Tissues were harvested from actively induced experimental autoimmune encephalomyelitis mice and sham-induced ("vehicle" control

SUBMITTER: Dagley LF 

PROVIDER: S-EPMC3945902 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature