Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.

ABSTRACT: Tumor recurrence after curative resection remains a major problem in patients with locally advanced colorectal cancer treated with adjuvant chemotherapy. Genetic single-nucleotide polymorphisms (SNP) may serve as useful molecular markers to predict clinical outcomes in these patients and identify targets for future drug development. Recent in vitro and in vivo studies have demonstrated that the plastin genes PLS3 and LCP1 are overexpressed in colon cancer cells and play an important role in tumor cell invasion, adhesion, and migration. Hence, we hypothesized that functional genetic variations of plastin may have direct effects on the progression and prognosis of locally advanced colorectal cancer. We tested whether functional tagging polymorphisms of PLS3 and LCP1 predict time to tumor rec

SUBMITTER: Ning Y 

PROVIDER: S-EPMC3945969 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature