Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals.

ABSTRACT:

Background

Interactions between the diet and intestinal microbiota play a role in health and disease, including obesity and related metabolic complications. There is great interest to use dietary means to manipulate the microbiota to promote health. Currently, the impact of dietary change on the microbiota and the host metabolism is poorly predictable and highly individual. We propose that the responsiveness of the gut microbiota may depend on its composition, and associate with metabolic changes in the host.

Methodology

Our study involved three independent cohorts of obese adults (n = 78) from Belgium, Finland, and Britain, participating in different dietary interventions aiming to improve metabolic health. We used a phylogenetic microarray for comprehensive fecal microbiot

SUBMITTER: Korpela K 

PROVIDER: S-EPMC3946202 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature