Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes.

ABSTRACT:

Background

Differences in gene or protein expression patterns between breast cancers according to race/ethnicity and cancer subtype.

Methods

Transcriptional profiling was performed using Affymetrix HG-U133A platform in 376 patients and reverse phase protein array analysis (RPPA) was done for 177 proteins in 255 patients from a separate cohort. Unsupervised clustering was conducted, as well as supervised comparison by race and tumor subtype. Standard statistical methods, BRB-Array tools, and Ingenuity Pathways software packages were used to analyze the data.

Results

Median age was 50 years in both the cohorts. In the RPPA cohort, 54.5% of the tumors were hormone receptor-positive (HR-positive), 20.7% HER2-positive, and 24.71% triple-negative (TNBC). One hundred and for

SUBMITTER: Chavez-Macgregor M 

PROVIDER: S-EPMC3946290 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature