Subcortical modulation of attentional control by second-generation antipsychotics in first-episode psychosis.

ABSTRACT: Psychotic disorders are characterized by significant deficits in attentional control, but the neurobiological mechanisms underlying these deficits early in the course of illness prior to extensive pharmacotherapy are not well understood. Moreover, little is known regarding the symptom and brain changes associated with amelioration of attentional impairments through antipsychotic pharmacotherapy. In this study 14 male patients experiencing a first-episode of psychosis with minimal prior antipsychotic treatment completed an attentional control task while undergoing functional magnetic resonance imaging at the onset of treatment with a second generation antipsychotic (risperidone or aripiprazole) in a double blind randomized clinical trial and then again following approximately 12 weeks of tr

SUBMITTER: Ikuta T 

PROVIDER: S-EPMC3946302 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature