Free-standing kinked nanowire transistor probes for targeted intracellular recording in three dimensions.

ABSTRACT: Recording intracellular (IC) bioelectrical signals is central to understanding the fundamental behaviour of cells and cell networks in, for example, neural and cardiac systems. The standard tool for IC recording, the patch-clamp micropipette is applied widely, yet remains limited in terms of reducing the tip size, the ability to reuse the pipette and ion exchange with the cytoplasm. Recent efforts have been directed towards developing new chip-based tools, including micro-to-nanoscale metal pillars, transistor-based kinked nanowires and nanotube devices. These nanoscale tools are interesting with respect to chip-based multiplexing, but, so far, preclude targeted recording from specific cell regions and/or subcellular structures. Here we overcome this limitation in a general manner by fabri

SUBMITTER: Qing Q 

PROVIDER: S-EPMC3946362 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature