A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer.

ABSTRACT:

Purpose

To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer.

Experimental design

Poor survival signatures from three different serous ovarian cancer datasets were compared and a common set of genes was identified. The predictive value of this gene signature was validated in independent datasets. The expression of the signature genes was evaluated in primary, metastatic, and/or recurrent cancers using quantitative PCR and in situ hybridization. Alterations in gene expression by TGF-β1 and functional consequences of loss of COL11A1 were evaluated using pharmacologic and knockdown approaches, respectively.

Results

We identified and validated a 10-gene signature (AEBP1, COL11A1, COL5A1, COL6A2, L

SUBMITTER: Cheon DJ 

PROVIDER: S-EPMC3946428 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature