Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes.

ABSTRACT: An unresolved problem in biological signal transduction is how particular branches of highly interconnected signaling networks can be decoupled, allowing activation of specific circuits within complex signaling architectures. Although signaling dynamics and spatiotemporal mechanisms serve critical roles, it remains unclear if these are the only ways cells achieve specificity within networks. The transcription factor Steroidogenic Factor-1 (SF-1) is an excellent model to address this question, as it forms dynamic complexes with several chemically distinct lipid species (phosphatidylinositols, phosphatidylcholines and sphingolipids). This property is important since lipids bound to SF-1 are modified by lipid signaling enzymes (IPMK & PTEN), regulating SF-1 biological activity in gene express

SUBMITTER: Blind RD 

PROVIDER: S-EPMC3946453 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature