Disease control implications of India's changing multi-drug resistant tuberculosis epidemic.

ABSTRACT:

Background

Multi-drug resistant tuberculosis (MDR TB) is a major health challenge in India that is gaining increasing public attention, but the implications of India's evolving MDR TB epidemic are poorly understood. As India's MDR TB epidemic is transitioning from a treatment-generated to transmission-generated epidemic, we sought to evaluate the potential effectiveness of the following two disease control strategies on reducing the prevalence of MDR TB: a) improving treatment of non-MDR TB; b) shortening the infectious period between the activation of MDR TB and initiation of effective MDR treatment.

Methods and findings

We developed a dynamic transmission microsimulation model of TB in India. The model followed individuals by age, sex, TB status, drug resistance status, an

SUBMITTER: Suen SC 

PROVIDER: S-EPMC3946521 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature