Fecal microbial composition of ulcerative colitis and Crohn's disease patients in remission and subsequent exacerbation.

ABSTRACT:

Background

Limited studies have examined the intestinal microbiota composition in relation to changes in disease course of IBD over time. We aimed to study prospectively the fecal microbiota in IBD patients developing an exacerbation during follow-up.

Design

Fecal samples from 10 Crohn's disease (CD) and 9 ulcerative colitis (UC) patients during remission and subsequent exacerbation were included. Active disease was determined by colonoscopy and/or fecal calprotectine levels. Exclusion criteria were pregnancy, antibiotic use, enema use and/or medication changes between consecutive samples. The microbial composition was assessed by 16S rDNA pyrosequencing.

Results

After quality control, 6,194-11,030 sequences per sample were available for analysis. Patient-specific shi

SUBMITTER: Wills ES 

PROVIDER: S-EPMC3946581 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature