Discordance of IGF-1 and GH stimulation testing for altered GH secretion in obesity.

ABSTRACT:

Objective

To investigate the concordance/discordance of IGF-1 and peak stimulated GH in identifying subjects with reduced GH secretion and to determine the physiological significance of any discordance in obese subjects.

Design, patients and methods

95 obese and 43 normal weight men and women underwent measurement of IGF-1 and GH stimulation testing with GH releasing hormone (GHRH)-arginine. Reduced IGF-1 and GH secretion were defined using pre-determined cut-points. Cardiovascular disease risk was determined by measuring carotid intima-media thickness (cIMT). In a second study, IGF-1 was measured in 52 obese men and women who underwent GH stimulation testing and overnight frequent blood sampling. The association of IGF-1 and peak stimulated GH with parameters of endogenous

SUBMITTER: Stanley TL 

PROVIDER: S-EPMC3946615 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature