Overexpression of OLC1 promotes tumorigenesis of human esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

OLC1 was recently identified to be a potential oncogene. However, the role of OLC1 in human esophageal cell carcinoma (ESCC) is unknown. The aim of this study was therefore to evaluate the expression of OLC1 in human ESCC from normal, premalignant, and malignant lesions, and to clarify the mechanisms by which OLC1 contributes to the progression of ESCC.

Experimental design

Two hundred and fourteen paired ESCC specimens, and an independent set from 28 ESCC patients, were used to analyze the correlation between OLC1 expression and the pathological characteristics of tumors using immunohistochemistry. Stable OLC1-overexpressing and OLC1-interfering esophageal cancer cells were established and a series of experimental methods were used to investigate the biological funct

SUBMITTER: Li X 

PROVIDER: S-EPMC3946619 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature