Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study.

ABSTRACT:

Background

Lipid metabolism and particularly high-density lipoprotein (HDL) may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with plasma HDL and other lipids, which may be confounded by the recently reported associations of AMD with HDL-related genes. We explored the association of AMD with plasma lipid levels and lipid-lowering medication use, taking into account most of HDL-related genes associated with AMD.

Methods

The Alienor study is a population-based study on age-related eye diseases performed in 963 elderly residents of Bordeaux (France). AMD was graded from non mydriatic color retinal photographs in three exclusive stages: no AMD (n = 430 subjects, 938 ey

SUBMITTER: Cougnard-Gregoire A 

PROVIDER: S-EPMC3946623 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature