Pilot trial: pregabalin on colonic sensorimotor functions in irritable bowel syndrome.

ABSTRACT:

Background

In prior studies, pregabalin reduced rectal or colonic pain in patients with irritable bowel syndrome and healthy adults, suggesting reduction of afferent function.

Aim

To assess effects of pregabalin on colonic compliance, sensory and motor functions in patients with constipation-predominant irritable bowel syndrome.

Methods

In a pilot, double-blind, placebo-controlled, parallel-group study, we tested oral pregabalin, 200mg, in 18 patients with constipation-predominant irritable bowel syndrome. With a barostatically controlled polyethylene balloon in the left colon, we assessed sensation thresholds and colonic compliance using ascending method of limits, sensation ratings over 4 levels of distension, fasting and postprandial colonic tone and phasic motilit

SUBMITTER: Iturrino J 

PROVIDER: S-EPMC3946640 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature